The Cytomorphological Characteristics of Non-small Cell Lung Cancer are Associated with Its Radiological Features

Lung cancer is the most frequent type of major cancer worldwide. Lung cancer is histopathologically divided into small cell carcinoma and non-small cell lung cancer (NSCLC). In, addition, the discrimination of the histological subtype in NSCLC is regarded as highly important when choosing chemotherapy agents, as their effects differ according to the histological subtype [1]. The 2015 World Health Organization (WHO) classification1 reflects the 2011 International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/ European Respiratory Society (ERS) classifications [2]. The guidelines recommend the classification of the major adenocarcinoma (ADC) subtypes according to the predominant histological pattern (primary pattern), and the estimation of the percentage of the other ADC patterns that may be present in a resected specimen (in increments of 5%; secondary pattern). Some investigators have used analyzed the impact of the sub-classification on the prognosis of the major subtypes of resected lung ADC, which include acinar, solid, papillary, lepidic and micropapillary [3-5]. In those studies, solid and micropapillary predominant ADC were shown to have significantly worse prognoses than the other predominant subtypes; thus, they were considered to have significant value in predicting death and recurrence in the IASLC/ATS/ERS ADC classification system. Rodriguaez et al. [6,7] investigated the subtyping of ADC according to the proposed IASLC/ ATS/ERS classification based on cytology samples and published articles. On the other hand, there have been many efforts to stratify The Cytomorphological Characteristics of Non-small Cell Lung Cancer are Associated with Its Radiological Features